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Scientists expose law Chikungunya virus mechanism will help develop new drugs
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2 French National Scientific Research Center, said a communique, the agency with the Pasteur Institute, by revealing the Chikungunya virus surface protein 3D structure, mastered the mechanism of virus invasion of cells, this discovery will help development of new antiviral drugs. The communiqué said, the researchers clearly observed with electron microscopy that the virus surface protein 3D structure, they found that the protein E1, E2, p62 and other mechanisms in the virus plays a key role. First of all, Chikungunya virus E2 with the help of the attached cell membrane and then is transported to endosomes, the acidic environment which will stimulate the activity of E1, in its role, the virus within the body integrated with the nuclear one, and took the opportunity to release of RNA in cells, which replicate more viruses. The completion of a cell after infection, the virus will re-combination of the protein surface, break through the help of the p62 acidic environment, looking for new communication goals. Chikungunya virus that causes chikungunya culprits. Chikungunya fever is a fever, rash and joint pain as the main feature of the acute infectious diseases, mainly in South Asia, Africa and other regions in central and eastern spread is currently no cure or vaccine prevention. The researchers said the spread of Chikungunya virus control mechanism will help to improve prevention and treatment of chikungunya.
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